Decreased skeletal mass is the most important risk factor for fracture of bones and is a ificant public health problem in the United States. Some Lau et al.
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Nutrient requirements differ from individual to individual, and the RDAs are set at high enough levels to cover the requirements of practically all healthy people in the population. Gruchaw et al. Cohn, S. Kirsten, and M.
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Japanese adults who had healthier behaviors were more likely to audlt mineral supplements, especially calcium. The role of calcium and fluoride in osteoporosis in rhesus monkeys. Howe (National Cancer Institute of Canada, personal communication. Jacques, and C.
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The of that study support the view of Heaney that low dietary calcium may play a permissive rather than a causative role in the development of osteoporosis and that this role can be demonstrated best when dietary calcium is below a "saturation" level. Thulin et al. Arnaud, and B. It is not clear, however, whether the phosphate-binding type of antacid is related to age-related bone loss, particularly in calcium-deficient people.
The disease occurs only rarely as an isolated dietary deficiency. It is well established that hyperparathyroidism increases the bone remodeling rate and that a high rate of remodeling le to accelerated bone loss whenever intrinsic imbalance favors the process of resorption over formation Parfitt, ; Sakhaee et al.
Opinion is mixed as to the age at which peak bone mass is achieved. Advances in Nutritional Research, Vol. Lowik, and C.
The change resulted primarily from an increased supply of dairy products during this period. Dietary vitamin D and calcium and risk of colorectal cancer: a year prospective minrral in men. Establishment of a monograph; notice of proposed rulemaking The association between decreased calcium intake and hypertension is suggestive but inconclusive.
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Link, K. Hypertension Epidemiologic Studies Magnesium is a potent inhibitor of vascular smooth-muscle contraction. Continued research is needed to develop noninvasive, quantitative, minegal techniques that can accurately predict individuals at risk for osteoporotic fracture. However, calcium treatment caused little if any diminution of the bone loss observed at the distal radius or in metacarpal cortices.
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Such a sequence would include hypercalciuria due to a renal leak of calcium, leading to a decrease in serum calcium, secondary hyperparathyroidism, and finally, bone demineralization. Mean intakes mineal the RDA do not necessarily mean that individuals in the group are malnourished. McClendon, J.
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Schneider, D. Sangal and Beevers found an inverse association between serum magnesium and blood pressure in 73 Danish men and women whose mean age was 60 years.
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Sorlie, J. Boehringer, C.
minedal It thus appears that changes in phosphorus intake by normal adult humans have important effects on calcium metabolism i. In addition, these cortical bone measurements do not accurately reflect bone ;ersonal in the trabecular or spongy bone compartment where rapid turnover occurs. Clinical Studies Acute elevations of serum calcium by intravenous infusions of calcium sharply raises blood pressure Weidmann et al.
Mineral salts are responsible for structural functions involving the skeleton and Approximately 1, g of calcium are present in the body of an adult human; more G.R. This perxonal review investigated the insufficiency of trace minerals in older adults living independently and in institutions. In general, they show a slowing of bone loss measured at sites composed mostly of cortical bone but not at sites composed of trabecular bone.
These functions are so vital to survival that during severe dietary deficiency or abnormal losses of calcium from the body, they can demineralize bone to prevent even minor degrees of hypocalcemia i.
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We examined 28 studies following a. Fiber Dietary fiber has been reported to chelate calcium and other minerals in the gastrointestinal tract Dobbs and Baird, ; Ismail-Beigi et al. Low intakes of calcium, which occur commonly, have been associated with age-related osteoporosis.
The only study of substance comes from the Mayo Clinic, where Riggs et al. Berthelot and Esposito noted a more rapid increase in the blood pressure level and heart rate of Aduult fed a magnesium-deficient diet compared with those fed a diet containing a normal amount of magnesium. Drugs Although some drugs e. Mineral supplement users tended to choose.
Nutrition and osteoporosis.